No. The OSFP and the QSFP-DD are two physically distinct form factors. If you have an OSFP system, then OSFP optics and cables must be used. If you have a QSFP-DD system, then QSFP-DD optics and cables must be used. By A***a on 11/10/2020

There are two form-factors defined for 400G optical modules and cables, the OSFP and the QSFP-DD. The OSFP stands for “Octal Small Form-factor Pluggable”. It is described as an “Octal” module because the electrical interface of an OSFP connector consists of 8 electrical lanes, running at 50Gb/s each, for a total of bandwidth of 400Gb/s. The QSFP-DD stands for “Quad Small Form-factor Pluggable–Double Density”. The electrical interface of a QSFP-DD connector also has 8 electrical lanes, running at 50Gb/s each, for a total bandwidth of 400Gb/s. The QSFP-DD form factor is similar to the QSFP form factor, except a second row of electrical contacts has been added to increase the number of high-speed electrical lanes from 4 (in a QSFP) to 8 (in a QSFP-DD). By D***. on 11/05/2020

The “2FR4” refers to 2x 200G-FR4 links, and has a reach of 2km using single-mode fiber. Each of the 200G FR4 links has 4 optical channels, multiplexed onto one fiber pair (1 Tx and 1 Rx per 200G link). A 400G-2FR4 module has 2 of these links, resulting in a total of two pairs of single mode fiber (or 4 fibers total), and a total of 8 optical channels. Each optical channel operates at 50Gb/s. The 2FR4 module uses a dual CS connector to connect to 2 fiber pairs. By C***a on 10/23/2020